Technology Overview

Polymerase Chain Reaction

Single Nucleotide Polymorphism

Gene Expression Profiling

Comparative Genomic Hybridization

The historic completion of the Human Genome Project in 2000 has enabled researches to develop a broad range of advanced molecular diagnostics. Recently, advanced molecular diagnostics have been used to obtain global perspectives of human disease, and to identify genetic markers important for diagnosis and therapy.

These applications have focused on the analysis of genetic alterations and gene expression patterns underlying the biological properties and clinical behavior of pathogenic diseases. This genome wide approach is required to understand the fundamental complexity of disease. For example, human cancer as a disease displays amazing heterogeneity, including gene amplifications, deletions, and genetic instability, even amongst tumors considered within the same class. Already, the products of microarray technologies have contributed to the discovery of new biomarkers for disease and have spurred the rapid growth of a multi-analyte paradigm for disease diagnosis and treatment.

The resulting “gene signatures”; groups of gene expression patterns associated with a disease or trait, offer the promise of improved disease staging, risk stratification, and treatment decisions. At CMDX, we believe these advanced technologies are poised to revolutionize personalized medicine.